Nature Wins Cardio-Flow (180 Count)

Important Brand Update: Ardis Labs is Now Nature Wins!

We’re excited to share that Ardis Labs is transitioning to Nature Wins, a brand dedicated to promoting health and well-being through nature's best remedies. This change aligns with Dr. Ardis’s vision to provide natural, drug-free solutions for a symptom-free life.

Why the Change?
After years as Ardis Labs, Dr. Ardis is rebranding to better reflect his mission to harness the power of nature for restoring health. The new name, Nature Wins, speaks to his belief that everything needed to support a healthy immune system can be found in nature.

What Stays the Same?
Rest assured, the quality and effectiveness of the products remain unchanged. Only the branding will feature the new name, Nature Wins, starting with the Taurine supplement.

Dr. Ardis’s Commitment to You
Through Nature Wins and The Dr. Ardis Show, Dr. Ardis is dedicated to reducing suffering and restoring health naturally, without reliance on drugs or vaccines. He’s excited to bring you even more natural health solutions under the new Nature Wins brand.

Thank you for being a part of this journey toward a healthier, symptom-free life through the healing powers of nature!

 

Cardio Flow emerges as a formidable companion in the domain of heart well-being. By skillfully blending essential amino acids like L-methionine and L-cysteine with a special fusion of Ayurvedic herbs and complementary nutrients, it unleashes a potent formula. This distinct concoction aims to offer holistic backing to blood vessels, enhancing their performance and fostering cardiovascular health. By nurturing the intricate equilibrium within the circulatory network, Cardio Flow becomes pivotal in bolstering heart vitality, promising sustained vigor and longevity to its proponents.

CARDIO FLOW DESCRIPTION

This oral formula uses the amino acids L-methionine and L-cysteine along with a proprietary blend of Ayurvedic herbs as well as other synergistic nutrients and herbs to support the blood vessels.

• Nature Wins offers an extensive line of vitamin and mineral supplements that are formulated to the highest standards.
• Our supplements are manufactured in the USA.
• Nature Wins leads the way in innovative and revolutionary products that support your immune system against stress, anxiety, and viruses that can constantly attack your immune system.
• Safety sealed, 180 Count

IMPORTANT INFORMATION

DIRECTIONS

For best results we recommend taking two (2) capsules per day, with out without food.

Pregnant or Nursing: Please consult your healthcare practitioner before use.

INGREDIENTS

Guggul Extract (Std. to 2.5% Guggulsterones) 300mg, Bromelain 200mg, L-Methionine 200mg, L-Cysteine 200mg, Cilantro Leaf Powder 200mg, Butchers Broom Extract (Rhizome) 100mg, Indian Elecampane Extract 0.5% (Root) 76mg, Arjuna Bark Extract (Std. to 0.5% Arjunolic Acid) 50mg, Bacopa Leaf Extract (Std. to 20% Bacosides) 50mg, Papain (525 TU/mg) 20mg, L-Glutathione 14 mg

Other ingredients: Vegtable Capsule (HPMC), rice hull, silicon dioxide

That's it! We don't hide ingredients. Everything that goes into every Nature Wins supplement is listed on the label.

SIX KEY BENEFITS OF SUPPLEMENTING L-GLUTATHIONE

L-glutathione is a naturally occurring antioxidant produced by the body. It plays a crucial role in maintaining overall health and well-being. Here are six key benefits of supplementing L-glutathione:

1. Boosts Immunity: L-glutathione helps to enhance the immune system by reducing oxidative stress in the body. It helps to strengthen the immune system's ability to fight off infections and diseases.

2. Improves Skin Health: L-glutathione is known to improve skin health by reducing the production of melanin, the pigment responsible for skin darkening. It also helps to protect the skin from UV damage and other environmental factors.

3. Detoxifies the Body: L-glutathione is an important detoxifier that helps to eliminate harmful toxins and heavy metals from the body. It also supports liver function by aiding in the removal of harmful substances from the body.

4. Reduces Inflammation: L-glutathione helps to reduce inflammation in the body, which is often the root cause of many chronic diseases such as arthritis, heart disease, and diabetes.

5. Enhances Athletic Performance: L-glutathione is known to improve athletic performance by reducing muscle damage and fatigue. It also helps to increase endurance and stamina.

6. Supports Brain Health: L-glutathione helps to protect the brain from oxidative stress and free radical damage, which can lead to cognitive decline and other neurological disorders. It also helps to improve memory and cognitive function.

Shipping Information

Domestic Orders: Nature Wins offers Free Shipping for all orders over $99 within the United States (domestic). ImmuneBoostNaturals.com only ships Nature Wins products to the 50 United States of America. For international orders, please follow the steps below.

For International Orders, please click this link to visit TheDrArdisShow.com and use code IBN for a 10% discount. 

RESEARCH STUDIES

Ingredient #1: Guggul Extract

Ability to lower blood sugar

• Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats
• https://linkinghub.elsevier.com/retrieve/pii/S0278691509003524
• Four groups of rats were fed high fat diet, for 16 weeks
• Guggulsterone demonstrated a differential effect with a significantly improved PPARgamma expression and activity in in vivo and in vitro conditions
• The results presented here suggest that the guggulsterone has both hypoglycemic and hypolipidemic effect which can help to cure type II diabetes.

Helps reduce triglyceride, total cholesterol, and LDL (bad) cholesterol levels

• A Comparative Study of Lipid-Lowering Effects of Guggul and Atorvastatin Monotherapy in Comparison to Their Combination in High Cholesterol Diet-Induced Hyperlipidemia in Rabbits
• https://www.tandfonline.com/doi/full/10.3109/19390211.2015.1118654
• Male New Zealand White rabbits were made hyperlipidemic by feeding cholesterol (0.5 g/kg) for three weeks and randomly divided into a control and three treatment groups receiving: atorvastatin (3.7 mg/kg), guggul (3.5 mg/kg) and their combination (same dose) for the next three weeks
• All treated groups had significant reduction in cholesterol, triglyceride, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) in comparison to pre-treatment values and control group, and had significant increase in high-density lipoprotein (HDL) in comparison to pre-treatment values.
• Combination of atorvastatin and guggul was comparable to their monotherapies in improving lipid profile.

Ingredient #2: Bromelain

Effective at alleviating swelling

• Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis
• https://pubmed.ncbi.nlm.nih.gov/24273953/
• 12 patients suffering from CRS with (CRS+NP) or without (CRS-NP) nasal polyps who had undergone prior sinus surgery were treated with bromelain tablets (500 FIP) for three months.
• Treatment with bromelain tablets (500 FIP) improved TSS, TRS and SNOT-20 GAV on average.
• This treatment was found to be more effective, however, for CRS-NP than for CRS+NP. The average intake was six tablets, equivalent to a daily dosage of 3000 FIP. No adverse events were observed.

Reduces inflammation

• Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis
• https://pubmed.ncbi.nlm.nih.gov/29176974/
• This study aimed to investigate the effect of purified fruit bromelain (PFB)-induced inhibition of epithelial TNFR in a rat colitis model.
• Our results showed that both TNFR1 and TNFR2 expression were significantly increased in a colitis model, and the increase was significantly reversed by PFB
• Colitis symptoms, including infiltration of inflammatory cells, cytokine profiles, epithelial cell apoptosis, and epithelial tight junction barrier dysfunction were significantly ameliorated by PFB
• purification of fruit bromelain increases its selectivity on TNFR2 inhibition. High expression of epithelial TNFRs in colitis was significantly counteracted by PFB

Combats cancer

• Bromelain's activity and potential as an anti-cancer agent
• https://www.sciencedirect.com/science/article/abs/pii/S0304383509005217?via%3Dihub
• Existing evidence derived from clinical observations as well as from mouse- and cell-based models suggests that bromelain acts systemically, affecting multiple cellular and molecular targets. In recent years, studies have shown that bromelain has the capacity to modulate key pathways that support malignancy
• It is now possible to suggest that the anti-cancer activity of bromelain consists in the direct impact on cancer cells and their micro-environment, as well as in the modulation of immune, inflammatory and haemostatic systems.

Ingredient #3: L-Methionine

Builds Bone Strength

• A methionine-restricted diet and endurance exercise decrease bone mass and extrinsic strength but increase intrinsic strength in growing male rats
• https://www.sciencedirect.com/science/article/pii/S0022316622008707?via%3Dihub
• After an 8-wk intervention period, exercise-trained rats had a 9.2% lower body weight (BW) than did sedentary rats (P < 0.05). Additionally, 0.17% Met-fed rats had 32% lower BW when compared with rats fed the other 2 diets (P < 0.05)
• Serum osteocalcin was lower in the 0.17% Met-Ex group compared with the other 2 exercise groups and the 0.17% Met group (P < 0.05). Serum concentrations of C-terminal telopeptide of type 1 collagen were lower in exercise-trained and 0.17% Met-fed rats than in sedentary rats and rats fed the other 2 diets (P < 0.05 for both)
• Rats fed the 0.17% Met diet had lower trabecular bone volume, bone mineralization activities, and bone mineral content (BMC; e.g., total, cortical, and spongy BMC) and bone mineral density (BMD; e.g., total and spongy BMD) indices compared with rats fed the other 2 diets (P < 0.05). Exercise-trained rats also had lower bone mineralization activity, trabecular osteoclast density, total BMC, cortical BMC, and total BMD compared with sedentary rats (P < 0.05)
• The results indicate that MR and endurance exercise caused lower whole bone mass, size, and/or strength but might enhance intrinsic bone strength.

Ingredient #4: L-Cysteine

Balances Blood Sugar Levels

• L-cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, and oxidative stress and inhibits NF-kappaB activation in the livers of Zucker diabetic rats
• https://www.sciencedirect.com/science/article/abs/pii/S0891584909001749?via%3Dihub
• Starting at the age of 6 weeks, ZDF rats were supplemented orally (daily gavage, 8 weeks) with saline placebo (D) or l-cysteine (LC; 1 mg/kg bw) and fed a high-calorie diet. Six-week-old rats without any supplementation were considered baseline (BL) rats.
• LC supplementation significantly lowered blood levels of glucose (18%, p= 0.05), glycated Hb (8%, p= 0.02), CRP (23%, p= 0.02), MCP-1 (32%, p= 0.01), and insulin resistance (25%)
• Although LC did not change blood hematocrit or levels of transaminases, it did lower alkaline phosphatase (29%, p= 0.01) levels

Has Antioxidant Properties

• Mechanisms underlying the cardioprotective effect of L-cysteine
• https://link.springer.com/article/10.1007/s11010-005-4817-y
• This study aimed to test the hypothesis that supplying hearts with 0.5 mM L-cysteine would preserve glutathione levels leading to an increased resistance to ischaemia reperfusion.
• Hearts treated with 0.5 mM L-cysteine showed a significantly higher recovery of rate pressure product (16,256+/- 1288 mmHg bpm vs. 10,324+/- 2102 mmHg bpm, p < 0.05) and a significantly lower release of LDH (0.54+/- 0.16 IU/g wet weight vs. 1.44+/- 0.31 IU/g wet weight, p < 0.05) compared to controls. Also, the L-cysteine treated group showed significantly better preservation of ATP and GSH during ischaemia in comparison to control.
• 0.5 mM L-cysteine may include: increased anaerobic energy production either directly or through reduced degradation of adenine nucleotides; direct scavenging of free radicals; and/or improved antioxidant capacity through glutathione preservation.

Ingredient #5: Cilantro leaf powder

Helps lower blood sugar

• Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats
• https://www.sciencedirect.com/science/article/abs/pii/S0378874111004363?via%3Dihub
• A single oral dose and after daily dosing for 30 days
• A single dose of CS-extract (20mg) or GLB suppressed hyperglycemia in OHH rats, and normo-glycemia was achieved at 6-h post-dose; there was no effect on lipids, TG or insulin, but IR decreased significantly.
• The hypoglycemic effect was lower in normal rats. In the sub-chronic study in OHH rats, the test substances (CS-extract>GLB) reduced plasma glucose (normoglycemia on Day 21), insulin and IR, TC, LDL-cholesterol, and TG.
• Atherosclerotic index decreased while cardioprotective indices increased only by CS-extract, with no effect on BW, urea or creatinine.
• Sub-chronic administration of CS-extract in OHH Meriones shawi rats normalized glycemia and decreased the elevated levels of insulin, IR, TC, LDL-cholesterol and TG

Benefits heart health

• Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities
• https://www.sciencedirect.com/science/article/abs/pii/S037887410800696X?via%3Dihub
• Cs.Cr (1-30 mg/ml) caused fall in arterial blood pressure of anesthetized animals, partially blocked by atropine. Cs.Cr produced vasodilatation against phenylephrine and K(+) (80 mM)-induced contractions in rabbit aorta and cardio-depressant effect in guinea-pig atria.
• Cs.Cr produced diuresis in rats at 1-10mg/kg. Bio-assay-directed fractionation revealed the separation of spasmogenic and spasmolytic components in the aqueous and organic fractions respectively.
• These results indicate that coriander fruit exhibits gut stimulatory, inhibitory and hypotensive effects mediating possibly through cholinergic, Ca(2+) antagonist and the combination of these mechanisms respectively. Diuretic activity adds value to its use in hypertension

Rich in immune-boosting antioxidants

• Evaluation of coriander spice as a functional food by using in vitro bioassays
• https://www.sciencedirect.com/science/article/abs/pii/S030881461401019X?via%3Dihub
• we investigated raw and roasted coriander seeds for their functional food quality using antioxidant, anti-inflammatory and human tumour cell proliferation inhibitory assays
• The hexane and methanolic extracts of raw and roasted coriander seeds showed identical chromatographic and bioassay profiles. Chromatographic purification of the roasted seed extracts afforded tripetroselinin as the predominant component. Other isolates were petroselinic acid, 1,3-dipetroselinin, 2-C-methyl-d-erythritol, 2-C-methyl-d-erythritol 4-O-β-d-glucopyranoside and linalool.
• Hexane and methanolic extracts of both raw and roasted seeds and pure isolates from them showed comparable antioxidant and anti-inflammatory activities to the positive controls used in the assays, and inhibited the growth of human tumour cells AGS (gastric carcinoma), DU-145 and LNCaP (prostate carcinoma), HCT-116 (colon carcinoma), MCF-7 (breast carcinoma) and NCI-H460 (lung carcinoma) by 4-34%, respectively.

Ingredient #6: Butcher's broom extract (Rhizome)

Reduce Symptoms of Orthostatic Hypotension

• Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report
• https://pubmed.ncbi.nlm.nih.gov/11152059/
• Ruscus aculeatus, a phytotherapeutic agent containing ruscogenins and flavonoids, may prove useful for the treatment of OH if denervation is not so advanced that it has compromised receptor activity at the venous wall. Ruscus aculeatus is an alpha-adrenergic agonist that causes venous constriction by directly activating postjunctional alpha1- and alpha2-receptors, in turn stimulating the release of noradrenaline at the level of the vascular wall
• It also possesses venotonic properties: it reduces venous capacity and pooling of blood in the legs and exerts protective effects on capillaries, the vascular endothelium, and smooth muscle. Its flavonoid content strengthens blood vessels, reduces capillary fragility, and helps maintain healthy circulation.
• Unlike most of the drug therapies used to treat OH, Ruscus aculeatus does not cause supine hypertension. It also appears to do something no other therapy can offer--alleviate the worsening effects of OH in environmentally hot conditions.
• Ruscus aculeatus shows great promise for ameliorating the symptoms of OH and improving the quality of life for large groups in the population.

Treat Poor Blood Circulation

• Meta-analysis of clinical trials of Cyclo 3 Fort in the treatment of chronic venous insufficiency
• A meta-analysis using data from all clinical trials and studies of Cyclo 3 Fort, a combination of root extract of the Ruscus aculeatus plant (150 mg per capsule), hesperidin methyl chalcone (150 mg) and ascorbic acid (100 mg)
• The meta-analysis included 20 placebo controlled, randomised, double blind studies and 5 randomised studies against a comparator drug.
• On a 4 point symptom severity scale, where 0 corresponds to no symptoms and 3 to severe symptoms, Cyclo 3 Fort significantly reduces the severity of pain by 0.44 (0.12) points; cramps 0.26 (0.08), heaviness 0.53 (0.11), and paraesthesia 0.29 (0.10) compared to placebo.
• There is also a significant reduction in venous capacity of 0.70 (0.19) ml/100 ml with Cyclo 3 Fort compared to placebo.
• We also found reductions in the severity of oedema 0.43 (0.20) points, and decreases in calf and ankle circumference, 0.73 (0.37) cms and 1.17 (0.83) cm, respectively, among patients treated with Cyclo 3 Fort compared to placebo which were not statistically significant.

Reduces Your Risk of Hemorrhoids

• Botanical Treatments for Hemorrhoids
• In one study, 69% of people taking a supplement containing butcher’s broom rated it an effective treatment for hemorrhoids that reduced pain, swelling and other symptoms
• https://www.liebertpub.com/doi/10.1089/act.2005.11.285
• (needs to be paid for)

Reduces Inflammation

• Ruscogenin ameliorates diabetic nephropathy by its anti-inflammatory and anti-fibrotic effects in streptozotocin-induced diabetic rat
• https://pubmed.ncbi.nlm.nih.gov/24666993/
• Diabetes was induced with STZ (60 mg/kg) by intraperitoneal injection in rats. Two weeks after STZ injection, rats in the treatment group were orally dosed with 0.3, 1.0 or 3.0 mg/kg ruscogenin for 8 weeks.
• Renal NF-κB activity, as wells as protein expression and infiltration of macrophages were increased in diabetic kidneys, accompanied by an increase in protein content of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in kidney tissues.
• All of the above abnormalities were reversed by ruscogenin treatment, which also decreased the expression of transforming growth factor-β1 and fibronectin in the diabetic kidneys.
• Our data demonstrated that ruscogenin suppressed the inflammation and ameliorated the structural and functional abnormalities of the diabetic kidney in rats might be associated with inhibition of NF-κB mediated inflammatory genes expression.

Ingredient #7: Indian Elecampane extract

Anti-Inflammatory Properties

• Inula helenium and Grindelia squarrosa as a source of compounds with anti-inflammatory activity in human neutrophils and cultured human respiratory epithelium
• https://www.sciencedirect.com/science/article/pii/S037887411834354X?via%3Dihub
• The effect on IL-8, IL-1β and TNF-α release by neutrophils and respiratory epithelium cell line (A549) was measured by enzyme-linked immunosorbent assay (ELISA).
• We confirmed the ability of selected extracts and compounds to suppress neutrophil binding to the epithelium surface via downregulation of β2 integrin. Alantolactone and grindelic acid have shown significant suppression of IL-8, TNF-α and IL-1β release comparable with budesonide, used as a positive control.

Haa Antioxidant Properties

• Antioxidant and anticancer activities of extract of Inula helenium (L.) in human U-87 MG glioblastoma cell line
• https://journals.lww.com/cancerjournal/fulltext/2018/14030/antioxidant_and_anticancer_activities_of_extract.33.aspx
• The 3'-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and lactate dehydrogenase assays were used to study antiproliferative and cytotoxic activities against U-87 MG cell after 48 h exposure.
• the aqueous extracts displayed antiproliferative and cytotoxic activities at high concentrations tested, particularly at 200 μg/ml, without causing to oxidative stress.

Ingredient #8: Arjuna bark extract

Aids blood sugar control

• Antihyperglycemic activity and antioxidant role of Terminalia arjuna leaf in streptozotocin-induced diabetic rats
• https://www.tandfonline.com/doi/full/10.3109/13880209.2010.516755
• Hyperglycemia was induced in rats by single intraperitoneal injection of streptozotocin (STZ, 65 mg/kg body weight). Three days after STZ induction, the hyperglycemic rats were treated with META orally at the dose of 100 and 200 mg/kg body weight daily for 15 days.
• META at the dose of 100 and 200 mg/kg orally significantly (P < 0.001) and dose-dependently reduced and normalized blood glucose levels as compared with that of STZ control group.
• Serum biochemical parameters were significantly (P < 0.001) restored toward normal levels in META-treated rats as compared with STZ control.
• META treatment also significantly (P < 0.001) decreased lipid peroxidation and recovered GSH level and CAT activity toward normal as compared with STZ control.
• The present study infers that T. arjuna leaf demonstrated remarkable antihyperglycemic activity in STZ-induced diabetic rats
• Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves β-cell function in streptozotocin-nicotinamide induced diabetic rats
• https://www.sciencedirect.com/science/article/abs/pii/S0378874115301252?via%3Dihub
• Diabetes was induced in Sprague Dawley (SD) rats by STZ–nicotinamide and thereafter diabetic rats were treated with three different doses of WF (100, 200 and 400 mg/kg body weight) respectively and glibenclamide as a positive control.
• The acute toxicity study showed non-toxic nature of all the three doses of WF. Further, studies on diabetic rats exhibited anti-hyperglycemic effects by upregulating serum insulin and C-peptide levels
• WF shown to ameliorate oxidative stress by downregulating LPO levels and augmenting the antioxidant enzyme (ABTS)
• histopathological analysis demonstrate recovery in the structural degeneration of β-cells mass of pancreas tissue with increase in the liver glycogen content of the diabetic rats
• result have shown slight alteration in the GLUT-2 and GLUT-4 protein expression with the highest dose of WFc treatment

High in antioxidants

• Effects of Terminalia arjuna bark extract on apoptosis of human hepatoma cell line HepG2
• https://www.wjgnet.com/1007-9327/full/v12/i7/1018.htm
• Human hepatoma cells were treated with different concentrations of ethanolic extract of T. arjuna and its cytotoxicity effect was measured by trypan blue exclusion method and lactate dehydrogenase leakage assay.
• T. arjuna inhibited the proliferation of HepG2 cells in a concentration-dependent manner.
• Apoptotic morphology was observed in HepG2 cells treated with T. arjuna at the concentrations of 60 and 100 mg/L. DNA fragmentation, accumulation of p53 and cleavage of procaspase-3 protein were observed in HepG2 cells after the treatment with T. arjuna.
• T. arjuna induced cytotoxicity in HepG2 cells in vitro

Lowers systolic blood pressure

• Anti-hyperglycemic and anti-hyperlipidaemic effect of Arjunarishta in high-fat fed animals
• https://www.sciencedirect.com/science/article/pii/S0975947616302479?via%3Dihub
• To evaluate the anti-hyperglycemic and anti-hyperlipidemic effect of Arjunarishta on high-fat diet fed animals.
• High-fat diet fed (HFD) Wistar rats were randomly divided into three groups and treated with phytochemically standardized Arjunarishta (1.8 ml/kg), and hydroalcoholic extract of T. arjuna (TAHA) (250 mg/kg) and rosuvastatin (10 mg/kg), for 3 months
• HFD increased fasting blood glucose, liver triglyceride, systolic blood pressure and gene expression of TNF-α, IRS-1 and PGC-1α.
• Treatment of AA and TAHA significantly reduced fasting blood glucose, systolic blood pressure, total cholesterol and triglyceride levels.
• These treatments significantly decreased gene expression of TNF-α (2.4, 2.2 and 2.6 fold change); increased IRS-1 (2.8, 2.9 and 2.8 fold change) and PGC-1α (2.9, 3.7 and 3.3 fold change) as compared to untreated HFD.
• Anti-hyperglycemic, anti-hyperlipidemic effect of Arjunarishta may be mediated by decreased TNF-α and increased PGC-1α and IRS-1.

Ingredient #9: Bacopa Leaf Extract

Prevents Lipid peroxidation

• Brain lipid peroxidation and alzheimer disease: Synergy between the Butterfield and Mattson laboratories
• https://www.sciencedirect.com/science/article/abs/pii/S1568163719304982?via%3Dihub
• One type of oxidative damage is lipid peroxidation, the most important index of which is protein-bound 4-hydroxy-2-trans-nonenal (HNE).
• This highly reactive alkenal changes the conformations and lowers the activities of brain proteins to which HNE is covalently bound
• lipid peroxidation is the first type of oxidative damage associated with amyloid β-peptide (Aβ), a 38-42 amino acid peptide that is highly neurotoxic and critical to the pathophysiology of AD
• The Butterfield laboratory is one of, if not the, first research group to show that Aβ42 oligomers led to lipid peroxidation and to demonstrate this modification in brains of subjects with AD and MCI.
• The Mattson laboratory, particularly when Dr. Mattson was a faculty member at the University of Kentucky, also showed evidence for lipid peroxidation associated with Aβ peptides, mostly in in vitro systems.
• this review outlines some of the individual and/or complementary research on lipid peroxidation related to AD published from our two laboratories either separately or jointly.

Helps lower blood pressure levels

• New Nutraceutical Combination Reduces Blood Pressure and Improves Exercise Capacity in Hypertensive Patients Via a Nitric Oxide–Dependent Mechanism
• https://www.ahajournals.org/doi/10.1161/JAHA.119.014923
• Sixty‐nine uncontrolled hypertension patients, aged 40 to 68 years, on antihypertensive medication were enrolled in 2 double‐blind studies.
• Forty‐five were randomized to placebo or a new nutraceutical combination named AkP05, and BP, endothelial function, and circulating nitric oxide were assessed before and at the end of 4 weeks of treatment.
• Twenty‐four patients were randomized to diuretic or AkP05 for 4 weeks and underwent a cardiopulmonary exercise test to evaluate the effects of AkP05 on functional capacity of the cardiovascular, pulmonary, and muscular systems
• The action of the single compounds contained in the AkP05 nutraceutical combination. AkP05 supplementation reduced BP, improved endothelial function, and increased nitric oxide release; cardiopulmonary exercise test revealed that AkP05 increased maximum O2 uptake, stress tolerance, and maximal power output
• AkP05 reduced BP and improved endothelial function, evoking increased nitric oxide release through the PKCα/Akt/endothelial nitric oxide synthase pathway and reducing reactive oxygen species production via NADPH‐oxidase inhibition.

Reduces inflammation

• Assessing the Anti-inflammatory Effects of Bacopa-Derived Bioactive Compounds Using Network Pharmacology and In Vitro Studies
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647831/
• Bacopa has the ability to reduce acute pain and inflammation by inhibiting the enzyme cyclo-oxygenase-2 (COX-2) and reducing COX-2-arbitrated prostanoid mediators. Moreover, the anti-inflammatory property may also be associated with the neuroprotective activity of Bacopa
• results revealed that, quercetin (QR) showed significant binding energies with inflammatory genes
• This existing study aimed to evaluate the efficacy of QR as a potent anti-inflammatory compound against lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages.
• The in vitro analysis concludes that QR effectively reduces the production of nitric oxide (NO) in LPS-induced RAW264.7 cells and downregulates the expression of COX-2 and iNOS genes due to the inhibitory potential of QR on LPS-stimulated NO production.
• Inhibition of lipoxygenases and cyclooxygenase-2 enzymes by extracts isolated from Bacopa monniera (L.) Wettst
• https://www.sciencedirect.com/science/article/abs/pii/S0378874108002201?via%3Dihub
• Carrageenan-induced rat paw edema, rat mononuclear cells and human whole blood assay were employed as in vivo and in vitro models.
• In carrageenan-induced rat paw edema, BME brought about 82% edema inhibition at a dose of 100mg/kg i.p. when compared to indomethacin (INDO) (3mg/kg) that showed 70% edema inhibition
• BME also significantly inhibited 5-lipoxygenase (5-LOX), 15-LOX and cyclooxygenase-2 (COX-2) activities in rat monocytes in vivo
• 5-LOX IC(50) values were 25 microg/ml for EtOAc, 68 microg/ml for bacosides and 2 microg/ml for nordihydroguaiaretic acid (NDGA) where as COX-2 IC(50) values were 1.32 microg/ml for EtOAc, 1.19 microg/ml for bacoside fraction and 0.23 microg/ml for indomethacin. EtOAc and bacoside fractions also brought about significant decrease in TNF-alpha release ex vivo

Ingredient #10: Papain

Eases muscle soreness

• The effects of protease supplementation on skeletal muscle function and DOMS following downhill running
• https://pubmed.ncbi.nlm.nih.gov/15161110/
• Ten matched pairs of male participants ran at a -10% grade for 30 min at 80% of their predicted maximal heart rate. The participants consumed two protease tablets (325 mg pancreatic enzymes, 75 mg trypsin, 50 mg papain, 50 mg bromelain, 10 mg amylase, 10 mg lipase, 10 mg lysozyme, 2 mg chymotrypisn) or a placebo four times a day beginning 1 day before exercise and lasting a total of 4 days
• The experimental group demonstrated superior recovery of contractile function and diminished effects of delayed-onset muscle soreness after downhill running when compared with the placebo group.
• Our results indicate that protease supplementation may attenuate muscle soreness after downhill running.

Helps heal wounds

• [Use and effectiveness of papain in the wound healing process: a systematic review]
• https://www.scielo.br/j/rgenf/a/yjsmMcZV5pc9cMcjxSzVwfF/?lang=pt
• Twenty-seven clinically healthy white rats were randomly divided into three groups and treated accordingly until the 21st day post-incision
• Rats treated with papain-based wound cleanser showed a progressive wound healing based on the wound reduction rates and histological analysis when compared with rats treated with distilled water and Betadine. Better collagen deposition and presence of skin organelles in rats treated with papain-based wound cleanser demonstrated its efficacy in promoting wound healing

Ingredient #11: L-Glutathione

Increases mobility for people with peripheral artery disease

• Effect of Glutathione Infusion on Leg Arterial Circulation, Cutaneous Microcirculation, and Pain-Free Walking Distance in Patients With Peripheral Obstructive Arterial Disease: A Randomized, Double-Blind, Placebo-Controlled Trial
• https://www.mayoclinicproceedings.org/article/S0025-6196(11)62019-3/abstract
• Forty patients with Fontaine stage II peripheral artery disease who were seen between September 2000 and March 2001
• The patients were randomly assigned (20 per group) to treatment with intravenous glutathione twice a day or saline solution twice a day for 5 days. Treatments were administered in a double-blind manner.
• All measurements and tests were repeated 12 hours after the last infusion.
• we observed increases in PFWD (196±15 vs 143±11 m; P<.04), macrocirculatory flow after treadmill test with plethysmography at the end of treatment (9.3±2 vs 2.8±0.5 mL per 100 mL/min; P<.002), and postischemic hyperemia with laser Doppler flowmetry, registered as perfusion units (PU), at the end of infusions (14.4±3.2 vs 6.18±1.5 PU; P<.005), with a greater area under the curve after treatment (705±103 vs 508±45 PU/s; P<.001) and reduced time to flow motion (32±4 vs 48±11 seconds; P<.05).

Improves psoriasis

• Psoriasis Improvement in Patients Using Glutathione-enhancing, Nondenatured Whey Protein Isolate: A Pilot Study
• https://pubmed.ncbi.nlm.nih.gov/24155989/
• Seven patients with psoriasis were recruited to take a nondenatured bioactive whey protein isolate, 20g orally per day, in addition to their current treatments, if any. Psoriasis Area and Severity Index scores and photographs were taken at baseline and monthly for three months.
• Patients with psoriasis were found to have a beneficial clinical improvement, whether they were on existing topical therapy, narrowband ultraviolet B, or no other treatment.

Glutathione - NIH

Glutathione and its antiaging and antimelanogenic effects